Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts

Fibroblast growth factor signalling in mouse mammary gland development.

Fibroblast growth factors (Fgfs) and their receptors are important intercellular signalling molecules involved in many aspects of animal development. The aberrant expression of the Fgfs or the inappropriate activation of their cell surface receptors have been implicated in tumorigenesis. Here, we describe the evidence that as well as playing a critical role in the formation of the mammary primo...

EGF, epithelium and Mammary Gland in Development & Cancer Guest Editors

02-P021 EDAR signalling in the mammary gland

correlates with recurrence within five years of surgery. To investigate the role of Notch signalling in tumour progression, characterized by increased proliferation, apoptosis resistance, epithelial–mesenchymal transition (EMT) and loss of polarity in 3D cultures, we have created an inducible NICD overexpressing MCF10A cell line. Furthermore, we have various breast cancer cell lines representat...

Canine Mammary Gland Cancer Stem Cell and its Potential Role in Malignant Biologic Behavior

BACKGROUND:Canine mammary gland cancers are the most prevalent malignancies in dogs. There are different challenges regarding management of these cancers in dogs and human, one hypothesis is related to small cellular subset of tumor mass called cancer stem cell. These cells are therapy resistant and cause metastasis and relapse even after primary successful treatment. The well-identified phenot...

Mammary gland development and cancer.

The mammary gland is a complex organ that begins development early in gestation and constantly changes in size, shape and function from the time of puberty to menopause. The earliest stages of embryogenesis appear to be independent of steroid hormones, whereas after the 15th week breast structure is largely influenced by a variety of hormones. In most females, further breast development begins ...